| Autor: |
Thanh, Hang Tran, Quoc, Tuan Vu, Van, Phu Nguyen, Quang, Loc Do, Ngoc, An Nguyen, Nhu, Chi Tran, Hoang, Nam Nguyen, Le, Ngoc Thanh, Nguyen, Tran Thuy, Bui, Tung Thanh, Duc, Trinh Chu |
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| Zdroj: |
Microsystem Technologies; Jul2022, Vol. 28 Issue 7, p1607-1619, 13p |
| Abstrakt: |
Microfluidic devices are increasingly being used as analytical systems, biomedical devices, chemistry and biochemistry instruments, and basic research systems. Fabrication of microfluidic devices using 3D printing and PCB technologies provides faster, less expensive routes to devices than the microelectronics-derived method. Since cleanroom is not a compulsory requirement and the entire fabrication process can be done in only one day, the proposed approach is more accessible to chemists and biologists working under benchtop conditions. In this work, the replica molding based on 3D printing for microfluidic channel realization and low-cost PCB manufacturing process for microelectrode structure formation were combined to apply in microfluidic device fabrication. Obtained results show that microfluidic channel structures can be fabricated with a success rate of up to 80% for the case of the 200-µm-in-dimension channel. Besides, a microfluidic lab-on-chip device capable of generating and sensing microdroplets was implemented to validate the usability of the proposed fabrication process. With the fabricated devices, microdroplets with sizes varying from 100 to 310 nL were successfully formed and detected based on the fluidic flow impedance detection technique. These results demonstrate that the combination of 3D printing and PCB technologies is a good option for the rapid prototyping of microfluidic devices aimed at complicating lab-on-a-chip (LoC) systems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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