Autor: |
Zhou, Fang, Zhang, Fengkui, Zhang, Li, Wu, Qian, Ma, Junjie, Zhao, Chunting, Wang, Ling, Jie, Guitao, Zhang, Haiyan, Zhang, Hao, Wang, Shunqing, Teng, Qingliang |
Zdroj: |
Annals of Hematology; Aug2022, Vol. 101 Issue 8, p1785-1794, 10p |
Abstrakt: |
Immunosuppressive therapy (IST) is an effective treatment regimen for severe aplastic anaemia (SAA) patients without HLA-identical donors. This study further compared the outcomes between IST and IIST-UCB in SAA on the basis of research shown that IST combined with umbilical cord blood infusion (IIST-UCB) treated effectively. A total of 123 patients from 11 hospitals in China were enrolled. Sixty-nine patients in IIST-UCB group were treated with ATG + CsA + CTX combined with cord blood, while 54 patients in IST group with ATG + CsA. The overall remission rates (ORRs), complete remission (CR) rates and partial response (PR) rates of IIST-UCB group and IST group at 3 months were 69.67% vs 51.85% (P =.045), 21.74% vs 3.7% (P =.004) and 47.83% vs 48.15% (P =.972), respectively. After 6 months of treatment, they were 76.81% vs 57.41% (P =.022), 37.68% vs 11.11% (P =.001) and 39.13% vs 46.30% (P =.425), respectively. After 1 year of treatment, they were 85.51% vs 61.11% (P =.002), 59.42% vs 25.93% (P =.000) and 26.09% vs 35.19% (P =.275), respectively. The ORRs and CR rates of IIST-UCB group were both significantly higher than IST group after 3 months, 6 months and 1 year of treatment. The neutrophil granulocyte, platelet and haemoglobin recovery times of IIST-UCB group were significantly shorter than IST group. Compared with standard IST, IIST-UCB as an effective therapy for SAA patients without HLA-identical donors accelerated the haematopoietic reconstitution, resulting in higher early CR rates. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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