| Autor: |
Medina‐Reyes, Estefany I., Rodríguez‐Ibarra, Carolina, Díaz‐Urbina, Daniel, Déciga‐Alcaraz, Alejandro, Delgado‐Buenrostro, Normal L., Chirino, Yolanda I., Pedraza‐Chaverri, José |
| Předmět: |
|
| Zdroj: |
Journal of Applied Toxicology; Aug2022, Vol. 42 Issue 8, p1411-1419, 9p |
| Abstrakt: |
Food‐grade titanium dioxide (E171) is widely used as a food additive, and it is known that after oral consumption, E171 is translocated into the bloodstream reaching the highest titanium level at 6 h. E171 is accumulated in some organs triggering toxicity, but the effects on the blood parameters after oral consumption have been less studied. Recently, evidence shows that oral exposure to E171 induces behavioral signs of anxiety and depression. The relation between blood alterations and psychiatric disorders has been previously demonstrated. However, the oral exposure to E171 effects on alterations in blood parameters and effects linked to alterations in animal behavior has not been explored. In this short communication, we aimed to investigate the effects of E171 on specific blood parameters (hematocrit, hemoglobin, number of erythrocytes, and leukocytes) and anxiety and compulsive‐like behavior in males and females orally exposed to ~5 mg/kg for 4 weeks. The results showed that E171 decreased hematocrit and hemoglobin in male but not in female mice while leukocyte and erythrocyte count remained unaltered. Oral consumption of E171 decreased the levels of anxiety‐like behavior in females but not in male mice, while compulsive‐like behavior was increased in both male and female mice. After oral consumption, food‐grade titanium dioxide (E171) is translocated into the bloodstream but the toxicity on blood parameters is poorly explored. Blood alterations are linked to psychiatric disorders; thus, we evaluated blood parameters and animal behavior after E171 exposure. Oral consumption of 5 mg/kgbw of E171 by drinking water for 4 weeks decreased hematocrit and hemoglobin in male but not in female mice. In addition, E171 induced compulsive‐like behavior in both sexes but decreased anxiety‐like behavior only in female mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text