| Autor: |
Santos, Thaís Garcia, Fernandes, Saffir Dominique, de Oliveira Araújo, Stefany Bruna, Felicioni, Fernando, de Mérici Domingues e Paula, Thaís, Caldeira-Brant, André Lucas, Ferreira, Soraia Viana, de Paula Naves, Luciana, de Souza, Stefânia Priscilla, Campos, Paulo Henrique Reis Furtado, Chiarini-Garcia, Hélio, Dias, Ana Luísa Neves Alvarenga, de Almeida, Fernanda Radicchi Campos Lobato |
| Předmět: |
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| Zdroj: |
Scientific Reports; 7/12/2022, Vol. 12 Issue 1, p1-10, 10p |
| Abstrakt: |
Intrauterine growth restriction (IUGR) compromises fetal development, leading to low birth weight, and predisposes to gastrointestinal disorders. Pigs that suffered IUGR present poor postnatal development, resulting in great economic losses to the industry. The small intestine may be involved with impaired development, but studies investigating this issue are still limited. Thus, the present study aimed to investigate small intestine morphofunctional alterations in IUGR pigs throughout the production phases (birth to 150 days). IUGR pigs presented lower body weight from birth to the finishing phase (P < 0.05). Although histomorphometrical parameters were not affected during the pre-weaning period, their commitment was observed specifically in the duodenum of the IUGR group at older ages (P < 0.05). The most detrimental effects on the small intestine, such as deeper duodenum crypts' depth, lower villus height:crypt depth ratio and absorptive area, increased apoptosis and lower proliferation of the duodenum epithelium were noticed at 70 days of age (P < 0.05). Additionally, IUGR pigs presented the lowest chymotrypsin and amylase activities at 70 and 150 days of age, respectively (P < 0.05). These findings may contribute to the elucidation of morphofunctional disorders of the small intestine in IUGR pigs throughout the different production phases, suggesting that poor postnatal development may be due to intestinal damage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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