| Autor: |
Wang, Kainan, Hu, Ye, Xu, Lingzhi, Zhao, Shanshan, Song, Chen, Sun, Siwen, Li, Xuelu, Li, Man |
| Zdroj: |
Molecular Biology Reports; Jul2022, Vol. 49 Issue 7, p6155-6160, 6p |
| Abstrakt: |
Background: Resistance to HER2-targeted therapy is a critical issue in breast cancer that must be addressed immediately. PIK3R1 mutations are more common in Chinese breast cancer patients (17%, 25/147, Fudan University Shanghai Cancer Center FUSCC vs. 1.8%, 87/4602, TCGA all breast cancer studies). However, very limited information is available on the relationship between PIK3R1 mutation status and resistance to HER2-targeted therapies in patients with HER2-positive breast cancer. Case report: We present a case of a HER2-positive advanced breast cancer patient with the PIK3R1EY451delinsD mutation who developed resistance to HER2-targeted therapy and had a better response to everolimus combined with trastuzumab and carboplatin. Conclusions: To the best of our knowledge, this is the first study to show that the PIK3R1EY451delinsD mutation confers resistance to anti-HER2 therapy in breast cancer and that combining with everolimus treatment may overcome this resistance mechanism. We hypothesize that the PIK3R1EY451delinsD mutation is associated with the resistance to anti-HER2 therapy, and that this mutation merits further investigation as a clinical biomarker and therapeutic target. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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