| Autor: |
Matsumoto, Shin, Nakayama, Masahiro, Gosho, Masahiko, Nishimura, Bungo, Takahashi, Kuniaki, Yoshimura, Tomonori, Senarita, Masamitsu, Ohara, Hirotatsu, Akizuki, Hiromitsu, Wada, Tetsuro, Tabuchi, Keiji |
| Zdroj: |
Laryngoscope; Aug2022, Vol. 132 Issue 8, p1582-1587, 6p |
| Abstrakt: |
Objectives/hypothesis: Postoperative complications may depend on the systemic inflammatory response. We evaluated the predictive potential of the combination of platelet count and neutrophil-to-lymphocyte ratio (COP-NLR) for the incidence of pharyngocutaneous fistula (PCF) in patients who have undergone total laryngectomy.Study Design: Retrospective cohort study.Methods: Patients who underwent total laryngectomy between 2000 and 2020 were recruited from four hospitals. The correlations between the incidence of PCF and several risk factors, including the COP-NLR, were examined. Patients with both elevated platelet count and elevated neutrophil-to-lymphocyte ratio (NLR) were categorized as COP-NLR 2, and patients with either one or no abnormal values of both parameters were assigned as COP-NLR 1 and COP-NLR 0, respectively.Results: A total of 235 patients were identified. The overall incidence of PCF was 12.3%. The cut-off value for NLR before surgery was set at 3.95 (sensitivity = 58.6%, specificity = 69.4%, area under the curve [AUC] = 0.635), and the platelet count was set at 320 × 109 /L (sensitivity = 27.6%, specificity = 87.9%, AUC = 0.571). Multivariate analysis revealed that COP-NLR was an independent risk factor for PCF (COP-NLR 1 vs. COP-NLR 0: odds ratio [OR], 4.17; 95% confidence interval [CI], 1.64 to 10.59; and COP-NLR 2 vs. COP-NLR 0: OR, 5.33; 95% CI, 1.38 to 20.56).Conclusions: COP-NLR is a novel predictive factor for the development of PCF in patients undergoing total laryngectomy.Level Of Evidence: 4 Laryngoscope, 132:1582-1587, 2022. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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