| Autor: |
El-Kalioby, Mona, EL-Komy, Mohamed H. M., Said, Eman R., Amer, Marwa Ahmed, Saadi, Dina G., Nouredin Mohammed, Faisal, Rashed, Laila A., El Desouky, Eman D., AlOrbani, Aya M. |
| Předmět: |
|
| Zdroj: |
Journal of Dermatological Treatment; Jun2022, Vol. 33 Issue 4, p2358-2363, 6p |
| Abstrakt: |
Growing evidence suggests the important role of IL-36 in the pathogenesis of psoriasis. Cathepsin G is a neutrophil-derived protease that can activate IL-36γ. To assess the expression of IL-36γ and cathepsin G in psoriasis and to quantify the impact of treatment with narrow-band ultraviolet B phototherapy (NB-UVB) on their levels. This case-control study involved 26 patients with moderate-severe psoriasis and 25 healthy volunteers. Psoriasis patients eligible for phototherapy received 24 NB-UVB sessions. Punch skin biopsies were obtained from all participants at recruitment and after phototherapy from patients. Real-time PCR was utilized for quantitative assessment of IL-36γ and cathepsin G expression in tissue samples. The expression of IL-36γ and cathepsin G was significantly higher in psoriasis before NB-UVB therapy compared to controls (p <.001). Both proteins decreased significantly with clinical improvement following NB-UVB therapy compared to baseline (p <.001). However, their expression after treatment was still higher than controls (p <.001). IL-36γ and cathepsin G expression is upregulated in psoriatic lesions, supporting their role as mediators of inflammation in psoriasis. Downregulation of IL-36γ and cathepsin G is a possible mechanism for psoriasis improvement after NB-UVB therapy. IL-36 and cathepsin G can be considered as therapeutic targets for psoriasis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
