| Autor: |
Mohseni Garakani, Mansoureh, Cooke, Megan E., Wertheimer, Michael R., Rosenzweig, Derek H., Ajji, Abdellah |
| Předmět: |
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| Zdroj: |
Plasma Processes & Polymers; Jul2022, Vol. 19 Issue 7, p1-15, 15p |
| Abstrakt: |
Bone metastasis is a frequent occurrence following breast cancer. The bone‐tumor microenvironment is heterogeneous and complicated to recapitulate. The development of new chemotherapeutics is ineffective partly due to a lack of precise in vitro tissue models. We developed a three‐dimensional (3D) bone‐tumor interface model for customized chemotherapeutic screening. It comprises a plasma‐modified electrospun mat seeded with osteoblasts to mimic a bone tissue, with a cell‐seeded hydrogel layer containing more and less aggressive or noncancerous cells on top, mimicking the tumor compartment. By screening the model with doxorubicin, we observed different migratory behaviors, with IC50 values that were largely in accordance with those cell lines' characteristics. Our 3D model reproduces the bone microenvironment and has great potential as a drug screening tool for personalized medicine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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