| Autor: |
Peng, Wenming, Benfadal, Said, Yu, Chunfeng, Wenzel, Jörg, Oldenburg, Johannes, Novak, Natalija |
| Předmět: |
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| Zdroj: |
Allergy; Jul2022, Vol. 77 Issue 7, p2253-2256, 4p |
| Abstrakt: |
Abbreviations 7-AAD 7-Aminoactinomycin D AD atopic dermatitis DMSO Dimethylsulfoxide Fc RI high-affinity receptor for IgE GAPDH glyceraldehyde-3-phosphate dehydrogenase IgE immunoglobulin E IL-4R IL-4 receptor alpha subunit JAK Janus kinase PKC protein kinase C STAT signal transducer and activator of transcription STAT3 signal transducer and activator of transcription 3 Syk spleen associated tyrosine kinase Th T helper ACKNOWLEDGMENTS We thank all the patients for their willingness to participate in the study. Upon allergen stimulation, sensitized basophils express the activation and degranulation marker CD63.5 We could show that baricitinib significantly suppressed allergen-mediated basophil activation and degranulation in a dose-dependent manner in vitro (Figure 1B and C, Figure S1, Table S1). JAK1/2 inhibitor but not IL-4 receptor alpha antibody suppresses allergen-mediated activation of human basophils in vitro. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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