| Autor: |
Frenkel, Yurii D., Cherno, Valerii S., Kostenko, Vitalii O. |
| Předmět: |
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| Zdroj: |
Romanian Journal of Diabetes Nutrition & Metabolic Diseases; 2022, Vol. 29 Issue 2, p194-201, 8p |
| Abstrakt: |
Background and aims: The aim of this work is to study the effect of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) inductor dimethyl fumarate (DMF) on the metabolic disorder and systemic inflammatory response in rats exposed to round-the-clock lighting (RCL) and kept on the high-calorie carbohydrate-lipid diet (HCLD). Materials and methods: The experiment was performed on 21 Wistar white male rats. Control rats (Group 1) were fed standard control chow and kept on 12/12 hours light / dark cycle. Rats of the Group 2 were kept on a HCLD for 8 weeks and exposed to RCL, thus simulating metabolic syndrome development. The animals of Group 3 received DMF in 10% dimethyl sulfoxide solution at a dose of 15 mg/kg intraperitoneally 3 times a week starting on the 30th day of the experiment. Results: DMF administered against the RCL and HCLD background lowered the serum glucose, insulin, cholesterol of very low-density lipoproteins and triglycerides levels and elevated the cholesterol of high-density lipoproteins concentration compared with the findings of Group 2. Administering DMF under RCL and HCLD reduced serum tumor necrosis factor-alpha, C-reactive protein, and blood thiobarbituric acid-reacting compounds concentration compared to the results in Group 2. Conclusions: The induction of the Nrf2 signaling system can be regarded as a potential target in the experimental therapy of metabolic syndrome, triggered by the disturbance of light / dark cycle and Western diet. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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