| Autor: |
Goukassian, David, Arakelyan, Arsen, Brojakowska, Agnieszka, Bisserier, Malik, Hakobyan, Siras, Hadri, Lahouaria, Rai, Amit Kumar, Evans, Angela, Sebastian, Aimy, Truongcao, May, Gonzalez, Carolina, Bajpai, Anamika, Cheng, Zhongjian, Dubey, Praveen Kumar, Addya, Sankar, Mills, Paul, Walsh, Kenneth, Kishore, Raj, Coleman, Matt, Garikipati, Venkata Naga Srikanth |
| Předmět: |
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| Zdroj: |
Clinical & Translational Medicine; Jun2022, Vol. 12 Issue 6, p1-6, 6p |
| Abstrakt: |
This pilot study suggests relatively short (median 12 days long) low-Earth orbit (LEO) spaceflight induces changes in circulating plasma small extracellular vesicle (sEV) microRNA expression. Batch effect assessment of variability of raw miRNA counts showed strong batch effects associated with inter-astronaut variability of miRNA expression (Figure S1B-D). Of note, sRNAseq was performed using RNA isolated from sEVs of 14 astronauts, while qPCR analysis could only be performed on seven astronauts due to the exceptionally rare sample availability. Space flight associated changes in astronauts' plasma-derived small extracellular vesicle microRNA: Biomarker identification. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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