| Abstrakt: |
Introduction: Cardiovascular disease (CVD) is the most common cause of death in patients with type 2 diabetes (T2D). The association between diabetes and cardiovascular disease is complex and multifaceted. This study aimed to investigate the possible association between rs8192688 Polymorphism of the FABP-4 gene and the CVD susceptibility in T2DM patients in Ilam Province, Iran. Material & Methods: The statistical population consisted of 210 cases (T2D patients with CVD [n=70], T2D patients without CVD [n=70], and healthy controls [n=70]). The frequency of polymorphisms was investigated using the Tetra-Primer-ARMS-PCR method. (Ethic code: IR.IAU.SHK.1399.011) Findings: The results showed that TG, HDL-C, and LDL-C in the T2D group with CVD were significantly increased, compared to those in the T2D group (P<0.05). The frequency rates of the CT genotype in the control, T2D, and T2D with CVD groups were 26%, 24%, and 295 (P=0.16), respectively. Moreover, the frequency rates of the TT genotype were 6%, 4%, and 4% (P=0.12), and the frequency rates of the T allele were 19%, 16%, and 19% (P=0.09), respectively. There was no significant relationship between this polymorphism and the studied groups. Discussion & Conclusion: The results showed that TG, LDL-C, and HDL-C could have a role in the development of CVD in T2D patients; however, the rs8192688 polymorphism of the FABP4 gene was not involved in the development of CVD in T2D patients. [ABSTRACT FROM AUTHOR] |
