MnO2 Nanozyme‐Loaded MXene for Cancer Synergistic Photothermal‐Chemodynamic Therapy.

Autor:	Li, Jingqi, Cai, Xinda, Zhang, Yihan, Li, Kangning, Guan, Lingyun, Li, Yilong, Wang, Ting, Sun, Tiedong
Předmět:	SYNTHETIC enzymes CATALYTIC activity TUMOR microenvironment MEDICAL lasers TUMOR treatment HIGH temperatures
Zdroj:	ChemistrySelect; 6/20/2022, Vol. 7 Issue 23, p1-7, 7p
Abstrakt:	Nanozymes, as an emerging representative of nanocatalytic technology, have recently been widely used in the treatment of tumors. However, considering the limitation of the tumor microenvironment (TME) on the catalytic activity of nanozymes, the efficacy of cancer therapy appears to be more resistant. In this paper, we have synthesized PVP/MnO2‐Ti3C2 composites by combining MXene and MnO2 nanozymes and modifying them with polyvinylpyrrolidone (PVP). MnO2 brings dual enzymatic activities to the composites. It can alleviate tumor hypoxia by O2 production and kill tumor cells by producing highly toxic ⋅OH. In addition, glutathione (GSH) overexpressed is also depleted. MXene brings PTT, which not only can ablate tumors using local high temperature under the irradiation of NIR laser but also further improves the efficacy of ROS. Thus, this study provides evidence for the enhanced efficacy of PTT in combination with CDT for tumors. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.