| Autor: |
Lin, Cheng, Lin, Keyu, Zhang, Bin, Su, Ying, Guo, Qiaojuan, Lu, Tianzhu, Xu, Yuanji, Lin, Shaojun, Zong, Jingfeng, Pan, Jianji |
| Předmět: |
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| Zdroj: |
Oncologist; Apr2022, Vol. 27 Issue 4, pe340-e349, 10p, 3 Charts, 4 Graphs |
| Abstrakt: |
Background Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV)-associated tumor that is highly common in southern China. Our previous sequencing data demonstrated that the EBV-encoded microRNA BART8-3p was most upregulated in nasopharyngeal carcinoma (NPC) and was closely associated with the metastasis of NPC. However, the values of plasma BART8-3p in NPC patients have not yet been well characterized. Material and Methods We quantified plasma BART8-3p expression by quantitative real-time PCR in 205 newly diagnosed NPC patients. Kaplan-Meier analysis was used to compare overall survival (OS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRRFS) between the groups. Results Plasma pretreatment BART8-3p was highly expressed in NPC patients compared with healthy controls. Pretreatment BART8-3p yielded a 92% predictive value for detecting NPC. Importantly, BART8-3p decreased dramatically after therapy relative to pretreatment levels. High levels of pretreatment or post-treatment BART8-3p were associated with worse OS, DMFS, and LRRFS. Multivariate analysis showed that high pretreatment or post-treatment BART8-3p was an independent unfavorable prognostic marker for OS (HR 3.82, 95% CI 1.77-8.24, P =.001 or HR 2.74, 95% CI 1.27-5.91, P =.010), DMFS (HR 2.82, 95% CI 1.36-5.85, P =.005 or HR 3.27, 95% CI 1.57-6.81, P =.002), and LRRFS (HR 1.94, 95% CI 1.12-3.35, P =.018 or HR 2.03, 95% CI 1.14-3.62, P =.016) in NPC. Subgroup analysis revealed that for patients with locally advanced NPC with high levels of pretreatment BART8-3p (n = 58), more cycles of chemotherapy (≥6 cycles) tended to prolong OS (P =.070). Over 50% (6/11) patients with high levels of post-treatment BART8-3p presented distant metastasis. Conclusion Plasma BART8-3p is a promising biomarker for the detection and prognosis of NPC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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