| Autor: |
do Nascimento, Ticiano Gomes, do Nascimento, Nataly Miranda, Ribeiro, Adriana Santos, de Almeida, Clinston Paulino, dos Santos, José Izaías Zacarias, Basílio-Júnior, Irinaldo Diniz, Calheiros-Silva, Fernanda Geny, Lira, Giselda Macena, Escodro, Pierre Barnabé, de Moraes Porto, Isabel C. C., da Silva, Valter Alvino, Dornelas, Camila Braga, dos Santos Sousa, Jonas, de Freitas, Johnnatan Duarte |
| Předmět: |
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| Zdroj: |
Journal of Thermal Analysis & Calorimetry; Jul2022, Vol. 147 Issue 14, p7837-7848, 12p |
| Abstrakt: |
The chitosan microcapsules containing Brazilian red propolis extract (RPE) obtained by spray-drying also called chitosanates of red propolis extract were prepared and characterized using techniques of particle size, scanning electron microscopy, infrared spectroscopy, thermal analysis, dissolution studies and antibacterial activity. An amount of five compositions of chitosanate hydrogels which were prepared at the concentrations between 16 and 75% of red propolis extract and characterized by particle size analysis showed 2 subpopulations of particle between 0.30 and 8.00 μm. The chitosanates in solid state obtained by spray-drying showed a rounded shape and particle diameter between 1.0 and 30 μm by SEM analysis. The thermal analysis and FTIR data demonstrate encapsulation of the bioactive red propolis extract into chitosan bio-polymeric system, and chemical reaction between chitosan and RPE was not detected. The chitosanates containing 35%, 50% and 75% of red propolis extract demonstrated in vitro release of flavonoids following a concentration-dependent and pH-dependent model. The modified release in simulate gastrointestinal tract conditions was proved. The chitosanates of red propolis extract obtained in the solid state were reversibly dissolved in chitosanate hydrogels in an appropriate dissolution medium to release the active flavonoids from the Brazilian red propolis extract. Antibacterial activity of chitosanates against Staphylococcus aureus was demonstrated. The chitosanates loaded with red propolis extract can be easily incorporated into food, in the production of biodegradable films, as a bio-preservative and can be manufactured by the pharmaceutical and nutraceutical industries as an intermediate bio-product in the form of powder for supplements, capsules and oral emulsifying systems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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