Embolization in pelvic venous disorders using ethylene vinyl alcohol copolymer (Onyx®) and Aetoxysclerol: a prospective evaluation of safety and long-term efficacy.

Autor: Jambon, E., Le Bras, Y., Coussy, A., Petitpierre, F., Hans, H., Lasserre, A., Cazalas, G., Grenier, N., Marcelin, C.
Zdroj: European Radiology; Jul2022, Vol. 32 Issue 7, p4679-4686, 8p, 1 Black and White Photograph, 1 Diagram, 2 Charts
Abstrakt: Objectives: To prospectively evaluate the safety and efficacy of embolization using ethylene vinyl alcohol copolymer (Onyx®) and Aetoxysclerol for treatment of pelvic venous disorders (PeVD). Methods: This prospective study was approved by the institutional ethics review board. Ten clinical parameters were retained for evaluation of PeVD (pelvic pain, dyspareunia, post-coital pain, menstruation pain, lower limbs pain, difficulty walking, aesthetic discomfort, impact on daily working life, psychological impact and impact on daily life), measured on a visual analogue scale (VAS) between 0 and 10, and a global score out of 100 was noted before embolization, after 3 months during the imaging follow-up, and at the end of follow-up by phone call. The main criterion was clinical efficacy of embolization defined by an impairment score < 40/100 and a 50% decrease in overall score. Complications were recorded. Visualization of Onyx® on MRI 3 months after embolization was noted. Results: Between July 2017 and May 2019, 73 consecutive women (mean age ± SD [range]: 41 ± 11 years [25–77]) treated by embolization with Onyx® and Aetoxysclerol were included. The median follow-up was 28 months [Q1–Q3: 24.0–29.2] (range: 18.1–34.5). The median initial VAS impairment score was 39/100 [29.75–48.50] (12–58). Clinical efficacy was obtained for 70 patients (70/73, 95.9%), and the median VAS impairment score at the end of follow-up was significantly lower at 3 [0.00–7.25] (0–73) (p < 0.0001). Four minor complications occurred. Onyx® was visualized on DIXON sequence of MRI for all patients. Conclusion: Embolization using Onyx® and Aetoxysclerol for PeVD is safe and effective. Key Points: • Embolization using Onyx®and Aetoxysclerol for pelvic venous disorders is safe and effective. • Imaging follow-up is facilitated by visualization of Onyx®on MRI DIXON sequences. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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