| Autor: |
Karmanova, E. E., Chernikov, A. V., Ivanov, V. E., Usacheva, A. M., Bruskov, V. I. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Jun2022, Vol. 56 Issue 3, p295-299, 5p |
| Abstrakt: |
α-Lipoic (thioctic) acid (ALA), which is used as a drug for the treatment of diabetic and alcoholic neuropathy and several other diseases, was found to be an effective antioxidant that effectively neutralized the products of water radiolysis and reduced oxidative damage to DNA and proteins caused by x-ray exposure. ALA had different effects on the formation and decay of long-lived reactive species of albumin and globulin in blood serum. This process was accompanied by the generation of hydrogen peroxide and prolongation of post-exposure oxidative stress. ALA in the concentration range 0.05 – 0.4 nM eliminated oxidative damage of DNA in vitro although the efficiency decreased with increasing concentration. ALA also exhibited genoprotective and radiomitigatory properties in vivo by reducing the formation of micronuclei in polychromatophilic erythrocytes of red bone marrow in mice after irradiation. The obtained results and available literature data indicate that ALA in the effective pharmaceutical window is a promising therapeutic radiomitigator capable of preventing harmful consequences caused by the disturbance of redox homeostasis due to radiation-induced oxidative stress. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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