Regulation of the type III InsP3 receptor and its role in β cell function.

Autor:	Hagar, R. E., Ehrlich, B. E.
Předmět:	INOSITOL PANCREATIC beta cells ION channels CALCIUM channels BILAYER lipid membranes
Zdroj:	Cellular & Molecular Life Sciences; Dec2000, Vol. 57 Issue 13/14, p1938-1949, 12p, 1 Color Photograph, 2 Diagrams, 4 Graphs
Abstrakt:	The type III inositol 1,4,5-trisphosphate receptor (InsP3R) is an important intracellular calcium (Ca2+) release channel in the pancreatic β cell. Pancreatic β cells secrete insulin following a characteristic change in membrane potential that leads to an increase in cytoplasmic Ca2+. Both extracellular Ca2+ and Ca2+ mobilized from InsP3-sensitive stores contribute to this increase. RIN-m5F cells, an insulin-secreting β cell line, preferentially express the type III InsP3R . These cells have been useful in determining the regulatory properties of the type III InsP3R and the role of this isoform in an intact cell. The type III InsP3R is ideal for signal initiation because high cytoplasmic Ca2+ does not inhibit its activity . Altered insulin secretion, the result of changes in Ca2+ handling by the β cell, has significant clinical consequences. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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