Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task.

Autor: Cornelissen, Frans W., Kimmig, Hubert, Schira, Mark, Rutschmann, Roland M., Maguire, Paul R., Broerse, Annelies, den Boer, Johan A., Greenlee, Mark W.
Předmět:
Zdroj: Experimental Brain Research; Jul2002, Vol. 145 Issue 2, p270-274, 5p
Abstrakt: We examined whether the frontal eye fields (FEF) are involved in the suppression of reflexive saccades. Simultaneous recording of horizontal eye movements and functional magnetic resonance imaging enabled us to perform a randomized pro- and antisaccade task and to sort blood oxygenation level dependent (BOLD) time series on the basis of task performance. Saccadic reaction time distributions were comparable across tasks indicating a similar effort in preprocessing of the saccades. Furthermore, we found similar BOLD activation in FEF during both correctly performed pro- and antisaccades. Frontal eye field activation started prior to target presentation and saccade generation. While we observed only few erroneous antisaccades, these were associated with a decrease in BOLD activity prior to target presentation, and increased BOLD activity after target presentation relative to correctly performed antisaccades. These findings are consistent with a role of the FEF in the suppression of reflexive saccades. The increase in activity after target presentation for antisaccade errors can only be indirectly linked to such a role but may also reflect activity related to the generation of a correction saccade. Frontal eye field BOLD activity may further represent general arousal, preparatory set, short-term memory, or salience-map related activity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: