Antioxidant Supplementation Protects Elite Athlete Muscle Integrity During Submaximal Training.
| Autor: | Gillam, Ian H., Cunningham, Ross B., Telford, Richard D. |
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| Předmět: |
BLOOD testing
MUSCULOSKELETAL system diseases RUNNING VITAMIN E BIOAVAILABILITY OXYGEN consumption ANTIOXIDANTS EXERCISE physiology CREATINE kinase MUSCLE fatigue VITAMIN C REGRESSION analysis DIETARY supplements PLACEBOS PRE-tests & post-tests RANDOMIZED controlled trials MUSCLE strength ENDURANCE sports BLIND experiment STATISTICAL sampling CROSSOVER trials |
| Zdroj: | International Journal of Sports Physiology & Performance; Apr2022, Vol. 17 Issue 4, p549-555, 7p, 1 Diagram, 1 Chart, 3 Graphs |
| Abstrakt: | Purpose: To determine (1) the effect of a 40-minute steady-state run on muscle membrane integrity of elite athletes as reflected by serum creatine kinase (CK), (2) whether antioxidant supplementation (AS) with vitamins E and C has a protective effect, and (3) if a minimal blood concentration of vitamin E or C is required for any such protection. Methods: Fifteen elite-level endurance athletes ( V ˙ O 2 max = 71.5 ± 1.2 mL · kg − 1 min − 1 ) were randomly assigned to 6 weeks AS (1000 IU·d−1 natural vitamin E and 1000 mg·d−1 vitamin C) or placebo. Using a double-blind crossover design and 4-week washout period, each treatment was followed by a 40-minute steady-state run at 3 mM blood lactate. Blood samples before and 0 and 24 hours after the run were assayed for serum and red cell α-tocopherol (α-TOH), serum ascorbate, and CK. Results: The AS produced a 2.5-fold, well-correlated (r =.84) increase in serum and red cell α-TOH (P <.001) that attenuated the increase in postrun CK (P =.01). There was no change in serum ascorbate with AS and no relationship with CK (P >.1). Curvilinear regression revealed some evidence that a critical level of serum α-TOH in the vicinity of 12 mg·L−1 was required to attenuate CK efflux, a level only achieved with AS. Conclusion: The muscle membrane integrity of elite-level athletes is compromised even during steady-state running of moderate intensity and duration. The AS provided a protective effect, with evidence that a serum α-TOH concentration of around 12 mg·L−1 is required. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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