A retrospective study comparing different injection approaches of 5-aminolevulinic acid in patients with non-melanoma skin cancer.

Autor: Zhao, Weihong, Wang, Jun, Zhang, Ying, Zheng, Baoyong
Předmět:
Zdroj: Journal of Dermatological Treatment; May2022, Vol. 33 Issue 3, p1465-1472, 8p
Abstrakt: 5-aminolevulinic acid through a needle-free, plum-blossom needle or conventional needle followed by photodynamic therapy are available options for non-melanoma skin cancer treatment. To compare these three techniques of injection of 5-aminolevulinic, regarding treatment response and adverse effects in patients with non-melanoma skin cancer. Non-melanoma skin cancer patients have received six cycles of 0.5 mL intralesional 20% w/v 5-aminolevulinic acid through a conventional needle (CPT cohort, n = 158), or plum-blossom needle (BPT cohort, n = 118), or needle-free injection (NPT cohort, n = 105) followed by irradiation with a red light. Data regarding treatment response and adverse effects were collected and analyzed. The treatment response was higher among patients of NPT cohort than those of CPT (p =.012, q = 3.981) and BPT (p =.012, q = 3.472) cohorts. Conventional and plum-blossom needle injections therapies were reported scar, local redness, and worse cosmetic appearance in the follow-up period. Needle-free injection of intralesional 5-aminolevulinic acid followed by irradiation with red light therapy were reported high treatment response with manageable adverse effects for non-melanoma skin cancer patients than that of conventional and plum-blossom needle injections. III. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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