Growth hormone does not affect albumin synthesis in the critically ill.

Autor: Barle, Hans, Gamrin, Lena, Essén, Pia, McNurlan, Margaret A., Garlick, Peter J., Wernerman, Jan, Barle, H, Gamrin, L, Essén, P, McNurlan, M A, Garlick, P J, Wernerman, J
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Zdroj: Intensive Care Medicine; May2001, Vol. 27 Issue 5, p836-843, 8p
Abstrakt: Objective: To study the effect of growth hormone (GH) on albumin synthesis in critically ill patients.Design: Prospective randomized controlled study.Setting: Two intensive care units, university hospital and county hospital, respectively.Patients: Twenty-two critically ill patients in the intensive care unit.Interventions: Albumin synthesis was measured twice in each patient, with a 5-day interval. The patients in the control group (n = 11) received standard intensive care unit (ICU) treatment between measurements, whereas those in the GH group (n = 11) also received 0.3 U/kg daily of human recombinant GH.Measurements and Results: Albumin synthesis was measured by labeling with L-[2H5]phenylalanine. In the control group, the fractional synthesis rate (FSR) of albumin was 16.3+/-4.1%/day (mean and SD) in the first measurement and 15.7+/-4.2%/day 5 days later (NS), whereas in the GH group the corresponding values were 17.0+/-4.7%/day and 16.7+/-5.5%/day (NS). The calculated absolute synthesis rates of albumin, based on FSR and intravascular albumin mass, also showed no effect of GH.Conclusion: Albumin synthesis rates were consistently higher in the two groups of critically ill patients than previously reported values in healthy subjects. However, GH treatment for 5 days neither stimulated nor inhibited albumin synthesis rates in these critically ill patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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