| Abstrakt: |
Important remaining questions about the consequences of maternal COVID-19 infection include the effects of infection in the first and second trimesters (most reports have focused on third trimester infections), the role of COVID-19 in preterm birth, and the long-term neurodevelopmental consequences of exposure to SARS-CoV-2 even in the absence of overt postnatal infection. The ongoing coronavirus disease (COVID-19) pandemic, caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to cause unprecedented disease with medical, social, and economic challenges across the globe. Abbreviations ADEM Acute disseminated encephalomyelitis CSF Cerebrospinal fluid MIS-C Multisystem inflammatory syndrome of children SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 What this paper adds Vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from mother to fetus is extremely rare. In a pilot study, nine children born to mothers with COVID-19 and nine age-matched controls were compared neurodevelopmentally at 8 to 10 months of age using the Ages and Stages Questionnaire, Third Edition.102 While children (none of whom developed COVID-19 disease postnatally) born to mothers with COVID-19 had lower Ages and Stages Questionnaire, Third Edition scores across multiple domains (communication, gross motor function, problem-solving, and personal-social), only deficits in fine motor performance reached statistical significance. [Extracted from the article] |
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