| Autor: |
Nara, Hidetoshi, Inoue-Murayama, Miho, Koshimura, Akiko, Sugiyama, Akinori, Murayama, Yuichi, Maejima, Masami, Ueda, Yuko, Ito, Hideyuki, Randi, Ettore, Heui-Soo Kim, Ji-Hong Ha, Kitagawa, Hitoshi, Takeuchi, Yukari, Mori, Yuji, Iwasaki, Toshiroh, Morita, Mitsuo, Ôta, Katuaki, Ito, Shin'ichi |
| Předmět: |
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| Zdroj: |
Animal Science Journal; Feb2005, Vol. 76 Issue 1, p81-86, 6p, 1 Chart |
| Abstrakt: |
Various dog breeds are remarkably different from each other not only in their sizes and shapes but also in behavioral traits, suggesting that some of these characteristics are under genetic control. However, little is known about genes related to behavioral traits in canine species. In humans, it has been reported that the dopamine receptor D4 gene (DRD4) includes polymorphism at several regions that relate to personality or psychiatric disorders. In an earlier study by the authors of the present study, the polymorphisms in canineDRD4exon III and exon I regions were reported. In the present study, a novel polymorphism in canineDRD4intron II was found based on a 17 base pair insertion/deletion, and the two alleles detected were namedP(shorter allele) andQ(longer allele). The allelic distribution in 28 breeds of dog, including a total of 1114 unrelated individuals, were then investigated. BothPandQalleles were detected in most of the breeds investigated; however, the frequencies ofPandQdiffered greatly between breeds. With respect to classification based on breed origin,PandQalleles were frequent in Occidental and Oriental breeds, respectively. Furthermore, two subspecies of wolves, the ancestors of dogs, were analyzed for the comparison of allele frequencies with dogs, and thePallele was predominant in both European and Chinese wolves. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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