β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging.

Autor: Maiti, Mrinmoy, Kikuchi, Kai, Athul, K. K., Kaur, Amandeep, Bhuniya, Sankarprasad
Předmět:
Zdroj: Chemical Communications; 6/4/2022, Vol. 58 Issue 44, p6413-6416, 4p
Abstrakt: A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence imaging. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index