Correction: Díaz-Talavera et al. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12 , 248.

Autor:	Díaz-Talavera, Alberto, Montero-Conde, Cristina, Leandro-García, Luis Javier, Robledo, Mercedes
Předmět:	DEOXYRIBOZYMES BIOMOLECULES CANCER treatment DNA synthesis HUMAN DNA DNA replication RIBONUCLEOSIDE diphosphate reductase CAMPTOTHECIN
Zdroj:	Biomolecules (2218-273X); May2022, Vol. 12 Issue 5, p693, 5p
Abstrakt:	In vitro, PrimPol can act as a DNA primase, elongating primers that PrimPol itself sythesizes, or as translesion synthesis (TLS) DNA polymerase, elongating pre-existing primers across lesions. In vivo, PrimPol DNA primase activity has been demonstrated; however, PrimPol TLS DNA polymerase action has not yet been probed. Yet, only in vitro, PrimPol is able to use its TLS capability when polymerizing in two different ways: on the one hand, by directly reading lesions, such as 8oxodG; and, on the other hand, by skipping non-readable lesions, such as AP sites, realigning the nascent primer ahead to continue the synthesis (Figure 3B). [Extracted from the article]
Databáze:	Complementary Index
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