| Autor: |
Li, Hang, Mirzayans, Paul M., Butler, Mark S., Lacey, Alastair E., Vuong, Daniel, Chen, Rachel, Kalaitzis, John A., Moggach, Stephen A., Lacey, Ernest, Piggott, Andrew M., Chooi, Yit-Heng |
| Předmět: |
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| Zdroj: |
Chemical Communications; 5/28/2022, Vol. 58 Issue 43, p6296-6299, 4p |
| Abstrakt: |
The brevijanazines are novel p-nitrobenzoylated piperazines isolated from Aspergillus brevijanus. Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and in vitro microsomal assays unveiled the biosynthetic pathway to the brevijanazines, featuring a cytochrome P450 oxygenase that converts p-aminobenzoic acid to p-nitrobenzoic acid. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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