| Autor: |
Liang, Ren-Xiao, Chen, Jian-Fei, Huang, Ying-Ying, Yu, Ya-Ping, Zhang, Han-Yue, Song, Yu-Feng, Tsui, Gavin Chit, Jia, Yi-Xia |
| Předmět: |
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| Zdroj: |
Chemical Communications; 5/25/2022, Vol. 58 Issue 42, p6200-6203, 4p |
| Abstrakt: |
Highly enantioselective palladium-catalyzed dearomative reductive Heck reaction and domino Heck–Suzuki reaction of 2-CF3-indoles have been developed. Using Pd(OAc)2/(R)-Synphos as the catalyst and Et3SiH as a hydride source, a variety of indolines bearing a 2-trifluoromethyl quaternary stereocenter were obtained via a dearomative reductive Heck reaction. Alternatively, using Pd(dba)2/phosphoramidite as the catalyst and Ar4BNa as a coupling partner, structurally diverse indolines containing two vicinal carbon stereocenters were afforded through the domino dearomative Heck–Suzuki reaction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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