Green Synthesis of Selenium Nanoparticles Mediated by Nilgirianthus ciliates Leaf Extracts for Antimicrobial Activity on Foodborne Pathogenic Microbes and Pesticidal Activity Against Aedes aegypti with Molecular Docking.

Autor: Meenambigai, Krishnan, Kokila, Ranganathan, Chandhirasekar, Kandasamy, Thendralmanikandan, Ayyavu, Kaliannan, Durairaj, Ibrahim, Kalibulla Syed, Kumar, Shobana, Liu, Wenchao, Balasubramanian, Balamuralikrishnan, Nareshkumar, Arjunan
Zdroj: Biological Trace Element Research; Jun2022, Vol. 200 Issue 6, p2948-2962, 15p
Abstrakt: The present study deals with the synthesis of selenium nanoparticles (SeNPs) using Nilgirianthus ciliatus leaf extracts, characterized by UV–Vis spectrophotometer, XRD, FTIR, FE-SEM, HR-TEM, DLS, and zeta potential analysis. The antimicrobial activity against Staphylococcus aureus (MTCC96), Escherichia coli (MTCC443), and Salmonella typhi (MTCC98) showed the remarkable inhibitory effect at 25 µl/mL concentration level. Furthermore, the characterized SeNPs showed a great insecticidal activity against Aedes aegypti in the early larval stages with the median Lethal Concentration (LC50) of 0.92 mg/L. Histopathological observations of the SeNPs treated midgut and caeca regions of Ae. aegypti 4th instar larvae showed damaged epithelial layer and fragmented peritrophic membrane. In order to provide a mechanistic approach for further studies, molecular docking studies using Auto Dock Vina were performed with compounds of N. ciliatus within the active site of AeSCP2. Overall, the N. ciliates leaf-mediated biogenic SeNPs was promisingly evidenced to have potential larvicidal and food pathogenic bactericidal activity in an eco-friendly approach. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: