| Autor: |
Oliveira-Costa, José Fernando, Meira, Cássio Santana, Neves, Maria Vitória Gomes das, Dos Reis, Bruna Padilha Zurita Claro, Soares, Milena Botelho Pereira |
| Předmět: |
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| Zdroj: |
Frontiers in Pharmacology; 5/23/2022, Vol. 13, p1-9, 9p |
| Abstrakt: |
Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide. Chronic diseases require long-term treatment frequently using corticosteroids and non-steroidal anti-inflammatory drugs, which are associated with diverse side effects and risk of toxicity. Betulinic acid, a lupane-type pentacyclic triterpene, is a potential lead compound for the development of new anti-inflammatory treatments, and a large number of derivatives have been produced and tested. The potential of betulinic acid and its derivatives has been shown in a number of pre-clinical studies using different experimental models. Moreover, several molecular mechanisms of action have also been described. Here we reviewed the potential use of betulinic acid as a promissory lead compound with anti-inflammatory activity and the perspectives for its use in the treatment of inflammatory conditions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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