Anticonvulsant activity and mechanism of actions of fractions of Ipomoea asarifolia (Desr) (Convolvulaceae) ethanol leaf extract.

Autor: Chiroma, Samaila S., Nazifi, Abdullahi B., Jamilu, Ya'u, Musa, Aliyu, Bichi, Lawal A., Chiroma, Samaila M.
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Zdroj: Bulletin of the National Research Centre; 5/23/2022, Vol. 46 Issue 1, p1-9, 9p
Abstrakt: Background: Preparation of Ipomoea asarifolia (Desr) (Convolvulaceae) is widely used in traditional African medicine for the treatments of different kinds of ailments such as syphilis, malaria, convulsions and rheumatism. Aim: The anticonvulsant properties of fractions of leaf of Ipomoea asarifolia (Desr); n-butanol (BF), chloroform, n-hexane and residual aqueous fractions (RAF) were evaluated on animals. Results: The RAF at dose of 75 mg/kg (P < 0.01) with 33% quantal protection and 83% protection against mortality is the most active fraction when compared with BF at 300 mg/kg (P < 0.01) with no quantal protection and 83% protection against mortality; the anti-seizure activity could be because of the presence of saponins (23.3%) and flavonoids (43.92%). The RAF may also owes its anticonvulsant activity via GABAergic pathway as flumazenil at 2 mg/kg significantly (P < 0.05) blocked the activity of RAF, via glutamatergic pathway with RAF (P < 0.05) significantly reversing the proconvulsive activity of ketamine at 200 mg/kg as compared to ketamine alone. Opioidergic pathway may also be implicated as naloxone 1 mg/kg significantly (P < 0.05) reduced the anticonvulsant effect of RAF. Conclusions: BF and RAF of leaf of Ipomoea asarifolia have shown anticonvulsants activities in PTZ-induced seizures. RAF was observed to be the most active fraction of Ipomoea asarifolia extract which probably exerts its action through GABAergic, glutamatergic and opioidergic pathways. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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