| Autor: |
Thanedar, Rohan, Kudva, Srinivas, Vijan, Suresh, Gokhale, Nitin, Sanzgiri, Prakash |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2022, Vol. 13 Issue 1, p731-736, 6p |
| Abstrakt: |
Background: In head-to-head studies, ST2 is often the most powerful biomarker predictor of risk; for example, ST2 was recently shown to be superior to galectin-3 in patients with chronic HF. ST2 can change significantly over time and serial measurement of ST2 adds independent and additive information to the baseline value and traditional risk factors in chronic HF if a rise and/or fall around the cut-off of 35 ng/mL is seen. ST2 levels may interact with specific HF therapies. Beta-blockers, angiotensin II receptor antagonists and mineralocorticoid receptor antagonists may influence ST2 values, opening the door for the possibility of guided HF therapy using serial measurement. Large, prospective trials are needed to evaluate this further. Methods: 30 In-patients and out-patients with chronic heart failure treated in Lilavati Hospital and Research Centre, Mumbai were observed over period of six months. Their Serum ST2 value and outcomes at the end of six months were studied. The study population included males and females, from different age groups and various etiological factors for heart failure. Standard statistical analysis methods were used to draw the conclusion. Observations: It was observed that amongst 30 patients, 11 patient died during 6 month study period and all of these patients had ST2 level more than 35 ng/ml, while 19 patient survived, of which 9 had ST2 level ≤ 35ng/ml and 10 had ST2 level more than 35 ng/ml.(p=0.011) ST2 level is associated significantly with the survival of patient. Conclusion: All patient who died during 6 month study period had ST2 level more than 35 and significant association was found between ST2 and Survival we can interpret that higher ST2 level associated with higher mortality in heart failure patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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