| Autor: |
Kolovou, Genovefa D., Anagnostopoulou, Katherine K., Pilatis, Nektarios D., Giannopoulou, Mirto, Hoursalas, Ioannis S., Pavlidis, Antonis N., Adamopoulou, Evdokia, Valaora, Alexandra I., Mikhailidis, Dimitri P., Cokkinos, Dennis V. |
| Předmět: |
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| Zdroj: |
Journal of Women's Health (15409996); Dec2004, Vol. 13 Issue 10, p1119-1126, 8p, 2 Charts, 1 Graph |
| Abstrakt: |
Heterozygous familial hypercholesterolemia (hFH) is a genetic disease that leads topremature atherosclerosis. Natural menopause leads to an adverse lipid profile and an enhancedrisk of coronary heart disease (CHD). Raised plasma triglyceride (TG) levels also contribute tothe risk of vascular events. The aim of this study was to evaluate the postprandial TG levels (aftera standardized fatty meal) in premenopausal and postmenopausal women with hFH.Thirty-three Greek women with hFH were divided into the premenopausalgroup= 16, mean age 34(SD = 7), mean total cholesterol = 330(30) mg/dl—and the postmenopausalgroup= 17, mean age 62(5), mean total cholesterol = 346(63) mg/dl. PlasmaTG concentrations were measured before and 2, 4, 6, and 8 hours after a standardized fat load.A value of>219 mg/dl (2.5 mmol/L) was taken as an abnormal response to the fat load, accordingto our previous studies.Postmenopausal women had higher TG levels at 2 (= 0.001), 4 (= 0.003), 6 (= 0.003), and 8 hours (= 0.005) after the fatty meal compared to premenopausal women. Fortyonepercent of postmenopausal hFH women had abnormal TG response (hFH-A) after a fattymeal, and such women had higher fasting TG levels than postmenopausal hFH women witha normal response to the fatty meal (hFH-N) (= 0.0014).Women with hFH tend to have an abnormal TG response to a fatty meal afterthe menopause. Fasting TG levels may be able to predict the abnormal response to a fatty meal. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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