| Autor: |
Sadek, Ayman Magd Eldin M., Khalil, Usama Ahmed, Abdallah, Abdallah Abdelaziz, SamyFawzi, Mohamed, Metwally, Fathya Abdelghaffar, Abdelrahman, Essam Adel |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2021, Vol. 12 Issue 7, p850-858, 9p |
| Abstrakt: |
Background: Diabetes mellitus (DM), the coming worldwide epidemic, markedly increases mortality by its cardiovascular complications. Growth Differentiation Factor (GDF)-15 is a promising tool for the detection of DM and its related cardiometabolic complications. Aim: Assessment of GDF-15 levels in type 2 DM with and without cardiovascular complications in comparison to control and to detect its relation to diabetes clinical and glycemic parameters to find out its diagnostic and prognostic value in these conditions. Patients and Methods: an observational descriptive case-control study included 96 subjects,32 of them were healthy volunteers and the remaining 64subjects have type 2 diabetes(32 patients of the last group without CV complications and the other 32 patients had cardiovascular complications). All subjects were subjected to full history, clinical examination, and routine laboratory investigations, in addition to measurement of GDF-15 level by ELISA .Results: GDF-15 in the present study was significantly increased in diabetics compared to controls and in complicated than the non-complicated group with a cutoff value of 170.13 for detection of diabetes and cutoff value of 327 for detection of CV complications with sensitivity and specificity above 65%. GDF-15 had a positive correlation with each of FBG, HbA1c, HOMA IR, TG, ESR and serum cholesterol also it was found that BMI, HbA1c, HOMA IR and TG are significant independent predictors to GDF-15 elevation in diabetic patients. Conclusion: GDF-15 elevation could be used as single or part of multi marker approach for diagnosis and prognosis for type 2 DM and its cardiovascular complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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