| Abstrakt: |
Background: Since the end of 2019, a new type of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) disease, named coronavirus disease 2019 (COVID-19), has spread all over the world and ever since has been designated as a pandemic that originated in Wuhan, China. The World Health Organization (WHO) has declared that the coronavirus outbreak has become a global health concern. Patients and methods: This retrospective cohort study was conducted at Covid Isolation Sednawy Hospital, Zagazig University during the period from 1/1/2021 to 30/4/2021. The study included 300 cases as a comprehensive sample; the patients were selected as severe to critical covid-19 patients in that work, according to the criteria of Egyptian protocol for management of COVID-19 patients (May, 2020). All patients had a laboratory diagnosis of COVID-19 based on real-time polymerase chain reaction (RT-PCR) in respiratory tract materials. Results: The Mean age of admitted patient 57±15.6 where male are more affected, There is statistically significant relation between severity and hemoglobin on admission within critical cases (P<0.001*).also, there is significant positive correlation between IL-6 and CRP value on admission. There is high statistical significant relation between severity and albumin and total protein on discharge. While increase mortality in critical cases, the best cutoff of neutrophil/lymphocyte ratio in prediction of mortality among patients is ≥8.8615 with area under curve 0.622, sensitivity 67.9%, specificity 50%, positive predictive value (PPV) 48.4%, negative predictive value (NPV) 69.3% and overall accuracy 57.3% (p<0.001). Conclusion: Admission characteristics were associated with the need for ICU admission; laboratory findings in the first day of hospitalization could be predictor factors of severity and mortality in ICU-admitted COVID-19 patients. [ABSTRACT FROM AUTHOR] |
