| Autor: |
Al-Baz, Aya A., Maarouf, Aref, Abdallah, Alshimaa L., Marei, Ayman |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2021, Vol. 12 Issue 7, p145-157, 13p |
| Abstrakt: |
The increasing appearance of multidrug resistance (MDR) among K. pneumoniae nosocomial isolates has confined the suitable therapeutic choices for the treatment. Carbapenems are a class of β-Lactam antibiotics with a broad spectrum of antibacterial activity. Misuse, overuse and abuse of the carbapenems can increase resistance in the K.pneumoniae carbapenemase (KPC)-producing bacteria. The production of carbapenemases especially KPC is the most important mechanism of enzymatic resistance in isolated Enterobacteriaceae such as K. pneumonia. KPCs are encoded by the gene bla-KPC, whose potential for different species and universal spreading is mainly elucidated by its location within a Tn3-type transposon, Tn4401. This transposon is able to inserting into varied plasmids of Gram-negative bacteria. Considering the fact that information on the subject is limited in our country so utilization of a suitable method for determination of the carbapenemase production is an important point in the microbiology laboratory. Therefore, the aim of this study was to review phenotypic and Genotypic Methods for Detection of Carbapenemase producing K. Pneumoniae. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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