Changes in the Expression of Pluripotency Factor Oct-4 and Intensity of Apoptosis in the Uterus during Spontaneous and Immune-Dependent Abortions in Mice.

Autor: Artem'eva, K. A., Stepanova, I. I., Bogdanova, I. M., Boltovskaya, M. N., Yaglova, N. V., Obernikhin, S. V., Ponomarenko, E. A.
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Zdroj: Bulletin of Experimental Biology & Medicine; Apr2022, Vol. 172 Issue 6, p765-769, 5p
Abstrakt: We studied the expression of pluripotency factor Oct-4 and the intensity of apoptosis in the uterus during spontaneous and immune abortions in mice. Increased expression of factor Bax and reduced protein Bcl-2 synthesis in cells of the decidual membrane and decreased Oct-4 expression in the myometrium and perimetrium were detected. Thus, both spontaneous and immune-dependent abortions impair the apoptosis processes in the decidua and the formation of a pool of Oct-4+ cells in the uterus. In immune-dependent abortions, the intensity of apoptosis of decidual cells was lower than in spontaneous abortion. Low expression of the transcription factor Oct-4 in the myometrium and perimetrium characterizes pregnancy failure irrespective of its mechanisms. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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