Pre-phase strategy to mitigate first cycle effect in diffuse large B cell lymphoma.

Autor: Rudresha, A. H., Hassan, Syed Adil, Sreevalli, A., Lokanatha, D., Babu, M. C. Suresh, Lokesh, K. N., Rajeev, L. K., Saldanha, Smitha, Thottian, Antony G. F., Sharma, Kanika, Jacob, Linu Abraham
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Zdroj: Journal of the Egyptian National Cancer Institute; 5/9/2022, Vol. 34 Issue 1, p1-5, 5p
Abstrakt: Context: Treatment-related toxicities in DLBCL (diffuse large B cell lymphoma) patients are higher in the initial phase of treatment (first cycle effect). Implementation of pre-phase treatment before definitive chemotherapy had been shown to alleviate some of these side-effects in a non-randomized study conducted earlier in our institute (Lakshmaiah et. al., Eur J Haematol 100:644-8, 2018). Aims: This study was aimed at validating the role of pre-phase treatment in newly diagnosed DLBCL patients. Settings and design: All newly diagnosed patients with DLBCL above the age of 18 years were evaluated for eligibility and prospectively enrolled. A single-arm prospective study was conducted at the Department of Medical Oncology, in our institute from July 2015 to December 2019. Methods and material: Patients received vincristine and prednisolone as pre-phase treatment for 7 days after which definitive chemotherapy was instituted on day 1. They were followed up for 30 days post-first cycle chemotherapy. Statistical analysis used: Paired Student's t tests and Wilcoxon signed-ranks test were used for comparison of various clinical variables as appropriate. P value of less than 0.05 was considered significant. Results: Among the 180 patients who were included in study, performance status improvement was noted in significant number of patients (p < 0.001). 38.4% achieved an ECOG (Eastern Cooperative Oncology Group) performance status of 0 post-pre-phase therapy. Febrile neutropenia was observed in 12.8% in the present cohort as compared to the historical non-pre-phase cohort (34%). Conclusions: Pre-phase therapy significantly improves the performance status and diminishes neutropenia rates in DLBCL patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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