| Autor: |
Kusnierczyk, Halina, Pajtasz-Piasecka, Elzbieta, Koten, Jan-Willem, Bijleveld, Caspaar, Krawczyk, Krzysztof, Den Otter, Willem |
| Předmět: |
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| Zdroj: |
Cancer Immunology, Immunotherapy; May2004, Vol. 53 Issue 5, p445-452, 8p |
| Abstrakt: |
We have compared the effect of one and up to four local IL-2 treatments of transplanted MC38 colon carcinoma. A single IL-2 treatment prolonged the survival time (p=0.015), but no cure was obtained. One local IL-2 treatment inhibited tumor growth for about 1 week. After the start of tumor regrowth, a further IL-2 injection was given. After four IL-2 injections 6 out of 13 mice were cured. Histological studies show that IL-2 induced a local vascular leakage syndrome leading to massive peritumoral edema and subsequent necrosis of tumor tissue. IL-2 also attracted infiltrating cells, mainly macrophages. Subsequent IL-2 injections led to complete tumor regression. We believe that the combination of necrotic tumor debris and the IL-2–induced macrophage reaction enhanced a tumor-specific immune response. This local IL-2 application was not toxic. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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