First glanders cases detected in Nepal underscore the need for surveillance and border controls.

Autor: P, Koirala, M, Maharjan, S, Manandhar, KR, Pandey, T, Deshayes, G, Wang, MA, Valvano, K, Laroucau
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Zdroj: BMC Veterinary Research; 4/6/2022, Vol. 18 Issue 1, p1-6, 6p
Abstrakt: Background: Glanders is a transmissible zoonotic disease caused by Burkholderia mallei that infects equids and humans. No glanders cases in equids were reported so far in Nepal. Case presentation: Following suspected glanders in animals with clinical signs in different regions in Nepal, serum samples were tested by CFT, ELISA and Luminex® tests. Two horses and a mule tested positive for glanders by all tests, while two other equids only tested positive by ELISA and Luminex®. Analysis of swabs and pus samples by a PCR system targeting B. mallei confirmed the presence of the bacterium in the samples collected from the 3 equids that yielded positive results in all serological tests. Genotyping of the three PCR positive samples with a SNP-based method identified a genotype closely related to the B. mallei strains circulating in India. Conclusion: Confirmation of glanders cases underscores the need of implementing a surveillance program in Nepal and a strict control of the animal movement across the borders. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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