Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort.

Autor: Suzuki, Shiori, Katagiri, Ryoko, Yamaji, Taiki, Sawada, Norie, Imatoh, Takuya, Ihira, Hikaru, Inoue, Manami, Tsugane, Shoichiro, Iwasaki, Motoki, for the Japan Public Health Center-based Prospective Study Group, Sawada, N., Tsugane, S., Iwasaki, M., Inoue, M., Yamaji, T., Katagiri, R., Miyamoto, Y., Ihira, H., Abe, S. K., Tanaka, S.
Předmět:
Zdroj: British Journal of Cancer; Jun2022, Vol. 126 Issue 10, p1481-1489, 9p
Abstrakt: Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations.Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods.Results: The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) (Ptrend < 0.001) for overall cancer compared to the bottom quartile of CRP. Among site-specific cancers, higher CRP levels were associated with an increased risk of colorectal, lung, breast, biliary tract, and kidney cancer, and leukaemia. These positive associations remained among participants after >3 years' follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity.Conclusion: Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: