| Autor: |
Külz, Martin, Fellner, Stephan, Rocktäschel, Jörg, Ceglarek, Uta, Willenberg, Anja, Kratzsch, Jürgen |
| Předmět: |
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| Zdroj: |
Clinical Chemistry & Laboratory Medicine; May2022, Vol. 60 Issue 6, p877-885, 9p |
| Abstrakt: |
Keywords: free thyroxine; immunoassay; interferences; method comparison; thyroid stimulating hormone (TSH) EN free thyroxine immunoassay interferences method comparison thyroid stimulating hormone (TSH) 877 885 9 05/12/22 20220501 NES 220501 Introduction Thyroid dysfunctions are commonly diagnosed by the identification of thyroid-specific symptoms in combination with the laboratory measurement of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in serum or plasma. Anamnesis of patients with an implausible TSH-FT4 constellation We detected a broad spectrum of diagnoses and medications in our study patients, but a specific disease as a cause of dubiously increased FT4 or FT3 values was not indicated (Supplementary Tables 2 and 3). Graph: Figure 1: FT4 values compared with TSH values for the selected sample (Cobas fT4>=20.5 pmol/L, Cobas TSH 0.4-10 mU/L, clinically euthyroid patients, among other criteria as described). Of note, our evaluation of FT4 results does not demonstrate that the Liaison FT4 and the Architect FT4 methods are preferable to the Cobas FT4 assay because the high number (100%) of elevated Cobas FT4 levels are a direct consequence of the sample selection criteria. [Extracted from the article] |
| Databáze: |
Complementary Index |
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