| Autor: |
Gasa, M. L., Moodley, Y., Gopalan, P. D. |
| Předmět: |
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| Zdroj: |
Surgical Chronicles; 2022, Vol. 27 Issue 1, p95-98, 4p |
| Abstrakt: |
Background: Preoperative platelet counts outside the normal laboratory reference interval (RI) are associated with postoperative complications, and thus have potential prognostic relevance. However, there are inherent differences in platelet counts between racial groups, and platelet RIs established in Caucasians might not be applicable to other populations. Accordingly, platelet RIs based on Caucasians might yield incorrect perioperative risk estimates in African settings. We tested this hypothesis in a sample of South African (SA) patients undergoing major abdominal surgery. Methods: We conducted retrospective chart reviews involving data from 422 patients who underwent laparotomy at a quaternary SA hospital. We stratified platelet count using the international (150-450 x109/L in both males and females) and local SA (171-388 x109/L in males and 186-454 x109/L in females) RIs. Receiver Operating Characteristic (ROC) curve statistics were used to determine the prognostic accuracy of the two RIs for postoperative mortality, with results presented as C-statistics with 95% confidence intervals (95%CI). Results: Thrombocytopenia (TCP, platelet count < lower limit of RI) was associated with postoperative mortality (p<0.001). Both RIs demonstrated similar prognostic accuracy for postoperative mortality (local SA RI C-statistic: 0.658, 95%CI: 0.586-0.731 and International RI C-statistic: 0.638, 95%CI: 0.564-0.712). The overall performance of both RIs was fair, suggesting that platelet count on its own might be insufficient for perioperative risk stratification purposes. Conclusion: TCP is associated with postoperative mortality in our setting. The prognostic accuracy for postoperative mortality was similar for both RIs. Preoperative platelet count may be useful if incorporated into a multifactorial perioperative risk index. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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