Derivatizing Nile Red fluorophores to quantify the heterogeneous polarity upon protein aggregation in the cell.

Autor: Sun, Rui, Wan, Wang, Jin, Wenhan, Bai, Yulong, Xia, Qiuxuan, Wang, Mengdie, Huang, Yanan, Zeng, Lianggang, Sun, Jialu, Peng, Congcong, Jing, Biao, Liu, Yu
Předmět:
Zdroj: Chemical Communications; 5/2/2022, Vol. 58 Issue 35, p5407-5410, 4p
Abstrakt: Protein aggregation in the cell is often manifested by the formation of subcellular punctate structures. Herein, we modulated the solvatochromism and solubility of Nile Red fluorophore derivatives to quantitatively study the polarity inside pathogenic protein aggregates, revealing structure- and protein-dependent polarity heterogeneity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index