| Autor: |
Pribic, Micaela R., Black, Aristide H., Beale, Asia D., Gauvin, Jessica A., Chiang, Lisa N., Rose, Jacqueline K. |
| Předmět: |
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| Zdroj: |
Frontiers in Behavioral Neuroscience; 4/29/2022, Vol. 16, p1-9, 9p |
| Abstrakt: |
Recent studies examining association of opposing responses, contrasting emotional valences, or counter motivational states have begun to elucidate how learning and memory processes can translate to clinical therapies for trauma or addiction. In the current study, association of opposing responses is tested in C. elegans. Due to its relatively simple and well-described nervous system, it was hypothesized that association of two oppositional stimuli presented in a delayed conditioning protocol would strengthen the behavioral response to the first stimulus (alpha conditioning). To test this, C. elegans were exposed to a tone vibration stimulus (to activate a mechanosensory-driven locomotor reversal response) paired with a blue light (to activate a forward locomotor response) at a 2-s delay. After five pairings, behavior was measured following a tone-alone stimulus. Worms that received stimulus pairing did not show an enhanced response to the first presented stimulus (tone vibration) but rather showed a marked increase in time spent in pause (cessation of movement), a new behavioral response (beta conditioning). This increase in pause behavior was accompanied by changes in measures of both backward and forward locomotion. Understanding the dynamics of conditioned behavior resulting from pairing of oppositional responses could provide further insight into how learning processes occur and may be applied. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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