Impact of HAS-BLED Score on outcome after percutaneous left atrial appendage closure: insights from the German Left Atrial Appendage Occluder Registry LAARGE.

Autor: Ledwoch, Jakob, Franke, Jennifer, Brachmann, Johannes, Lewalter, Thorsten, Akin, Ibrahim, Senges, Jochen, Hochadel, Matthias, Zeymer, Uwe, Weiß, Christian, Krapivsky, Alexander, Sievert, Horst
Zdroj: Clinical Research in Cardiology; May2022, Vol. 111 Issue 5, p541-547, 7p
Abstrakt: Aim: Percutaneous left atrial appendage (LAA) closure has been established as alternative stroke prophylaxis in patients with non-valvular atrial fibrillation (AF) and high bleeding risk. However, little is known regarding the outcome after LAA closure depending on the HAS-BLED score. Methods: A sub-analysis of the prospective, multicenter, Left-Atrium-Appendage Occluder Register—GErmany (LAARGE) registry was performed assessing three different groups with respect to the HAS-BLED score (0–2 [group 1] vs. 3–4 [group 2] vs. 5–7 [group 3]). Results: A total of 633 patients at 38 centers were enrolled. Of them, 9% (n = 59) were in group 1, 63% (n = 400) in group 2 and 28% (n = 174) in group 3. The Kaplan–Meier estimated 1-year composite of death, stroke and systemic embolism was 3.4% in group 1 vs. 10.4% in group 2 vs. 20.1% in group 3, respectively (p log-rank < 0.001). The difference was driven by death since stroke and systemic embolism did not show a significant difference between the groups. The rate of major bleeding at 1 year was 0% vs. 0% vs. 2.4%, respectively (p = 0.016). Conclusion: The present data show that patients had similarly low rates of ischemic complications 1 year after LAA closure irrespective of the baseline bleeding risk. Higher HAS-BLED scores were associated with increased mortality due to higher age and more severe comorbidity of these patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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