| Autor: |
Kojima, Takashi, Shindo, Yuma, Konno, Takumi, Kodera, Yuki, Arai, Wataru, Miyakawa, Maki, Ohwada, Kizuku, Tanaka, Hiroki, Tsujiwaki, Mitsuhiro, Sakuma, Yuji, Kikuchi, Shin, Ohkuni, Tsuyoshi, Takano, Kenichi, Watanabe, Atsushi, Kohno, Takayuki |
| Předmět: |
|
| Zdroj: |
Tissue Barriers; 2022, Vol. 10 Issue 2, p1-15, 15p |
| Abstrakt: |
Airway and intestinal epithelial permeability barriers are crucial in epithelial homeostasis. High mobility group box 1 (HMGB1), increased by various stimuli, is involved in the induction of airway inflammation, as well as the pathogenesis of inflammatory bowel disease. HMGB1 enhances epithelial hyperpermeability. Two-and-a-half dimensional (2.5D) culture assays are experimentally convenient and induce cells to form a more physiological tissue architecture than 2D culture assays for molecular transfer mechanism analysis. In 2.5D culture, treatment with HMGB1 induced permeability of FITC-dextran into the lumen formed by human lung, nasal and intestinal epithelial cells. The tricellular tight junction molecule angulin-1/LSR is responsible for the epithelial permeability barrier at tricellular contacts and contributes to various human airway and intestinal inflammatory diseases. In this review, we indicate the mechanisms including angulin-1/LSR and multiple signaling in dysfunction of the epithelial permeability barrier induced by HMGB1 in 2.5D culture of human airway and intestinal epithelial cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
