| Autor: |
Hirano, Rika, Kume, Aiko, Nishiyama, Chisato, Honda, Ryosuke, Shirasawa, Hideto, Ling, Yiwei, Sugiyama, Yuta, Nara, Misaki, Shimokawa, Hiromi, Kawada, Hiroki, Koyanagi, Takashi, Ashida, Hisashi, Okuda, Shujiro, Matsumoto, Mitsuharu, Takagi, Hiroki, Kurihara, Shin |
| Předmět: |
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| Zdroj: |
Microorganisms; Apr2022, Vol. 10 Issue 4, pN.PAG-N.PAG, 14p |
| Abstrakt: |
Polyamines are aliphatic hydrocarbons with terminal amino groups and are essential for biological activities. It has been reported that polyamines have health-promoting effects in animals, such as the extension of lifespan by polyamine intake. The identification of a high polyamine-producing bacterium from foods could lead to the development of a novel probiotic candidate. We aimed to identify high polyamine-producing bacteria from food, and isolated and collected bacteria from vegetables and fermented foods produced in Japan. We successfully acquired Latilactobacillus curvatus KP 3-4 isolated from Kabura-zushi as a putrescine producing lactic acid bacteria. Comparing the polyamine synthesis capability of L. curvatus KP 3-4 with that of typical probiotic lactic acid bacteria and L. curvatus strains available from the Japan Collection of Microorganisms, it was found that only L. curvatus KP 3-4 was capable of exporting high levels of putrescine into the culture supernatant. The enhancement of putrescine production by the addition of ornithine, and whole-genome analysis of L. curvatus KP 3-4, suggest that putrescine is synthesized via ornithine decarboxylase. The administration of L. curvatus KP 3-4 to germ-free mice increased the concentration of putrescine in the feces. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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