| Autor: |
Sato, Atsushi, Kurihara, Minoru, Matsukawa, Masaaki, Shimada, Ken, Yamazaki, Takeshi, Nakamachi, Masatoshi, Koda, Takahiko, Sato, A, Kurihara, M, Matsukawa, M, Shimada, K, Yamazaki, T, Nakamachi, M, Koda, T |
| Předmět: |
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| Zdroj: |
Cancer Chemotherapy & Pharmacology; May2001, Vol. 47 Issue 5, p380-384, 5p |
| Abstrakt: |
Purpose: Irinotecan hydrochloride shows a strong activity against gastric cancer and colorectal cancer, while combined therapy with irinotecan and cisplatin is useful for gastric cancer. However, myelosuppression and diarrhea are still dose-limiting factors. To reduce such toxicities to enable therapy to be performed on an outpatient basis, we tested the effect of divided administration of cisplatin.Methods: Irinotecan (60 mg/m2) plus cisplatin (30 mg/m2) were administered on days 1 and 15 every 4 weeks to 13 patients with advanced gastric cancer and 13 with advanced colorectal cancer. Treatment was continued if a leukocyte count > or = 3000/mm3, a platelet count > or = 100,000/mm3, and grade 0 diarrhea were confirmed. Doses were reduced if grade 3-4 hematological toxicity and grade 2 or higher nonhematological toxicity occurred.Results: The major toxicity was leukopenia (neutropenia), but grade 3-4 nonhematological toxicity was not observed. The response rate was 41.7% for gastric cancer (5/12 evaluable patients) and 36.7% for colorectal cancer (4/11 evaluable patients). The median survival time was 313 days (range 29-920 days) for gastric cancer patients and 490 days (range 83-1184 + days) for colorectal cancer patients.Conclusion: Fortnightly administration of irinotecan and cisplatin (with a divided cisplatin dose) seems to be a useful regimen for gastrointestinal cancer. It reduces toxicity while maintaining a good antitumor effect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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