Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.

Autor:	Li, Hongjun, Wang, Zejun, Ogunnaike, Edikan A, Wu, Qing, Chen, Guojun, Hu, Quanyin, Ci, Tianyuan, Chen, Zhaowei, Wang, Jinqiang, Wen, Di, Du, Hongwei, Jiang, Jie, Sun, Jie, Zhang, Xingcai, Dotti, Gianpietro, Gu, Zhen
Předmět:	TRANSFORMATIVE learning ANTINEOPLASTIC agents B cell lymphoma T cells CHIMERIC antigen receptors SOWING
Zdroj:	National Science Review; Mar2022, Vol. 9 Issue 3, p1-10, 10p
Abstrakt:	Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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